There are two main reasons that lead to
liver failure; choric liver failure and acute liver failure. Chronic liver
failure is one when the liver fails as a result of damage over many months or
years. While in acute liver failure an extensive damage to the liver occurs
over a short period of time. The main causes of chronic liver failure include
alcoholic liver disease, Hepatitis C, Primary Biliary Cirrhosis, Hepatitis B, Primary
Sclerosing Cholangitis, Biliary Atresia, Autoimmune Hepatitis, Liver Cancer
etc.
However, acute liver failure is less common then
chronic liver failure. But that is acute liver failure only which necessitates emergency
liver transplant and is also largely associated with the high mortality
rate. The most common indications for liver transplantation include hepatitis C
virus (30%) and alcoholic liver disease (18%). However, other indications are
Idiopathic/autoimmune liver disease (12%), Primary biliary cirrhosis (10%),
Primary sclerosing cholangitis (8%), Acute liver failure (7%), Hepatitis B
virus (6%), Metabolic liver disease (eg, inborn errors of metabolism) (3%),
Cancer (3%), and Other (3%).